Fresenius Medical Care offers a concentrate product line based on best practice dialysate composition. Improvements in dialysis machine technology have eliminated the need to offer three different proportioning ratios. We have streamlined our acid concentrates product offering into a new 45X dilution series. The new series of NaturaLyte and GranuFlo concentrates have a dextrose concentration of 100 mg/dL, a magnesium (Mg) concentration of 1.0 mEq/L, and a sodium (Na) 100 mEq/L.

The potential clinical benefits of Fresenius improved dialysate include:

• Less frequent and severe hypoglycemic episodes ¹
• Lower amounts of glucose lost in effluent dialysate ¹
• Less fatigue ⁵
• Helps prevent vascular calcification in hemodialysis patients ^3,4
• Less intradialytic hypotension ^3,4
• Potentially lower mortality risk ⁶

References:
1 Burmeister JE, Scapini A, da Rosa MD, da Costa MG, Campos BM (2007). Glucose-added dialysis fluid prevents asymptomatic hypoglycemia in regular haemodialysis. Nephrol Dial Transplant 22:1184-1189.
2 Ishimura, E., et al. (2007). Significant association between the presence of peripheral vascular calcification and lower serum magnesium in hemodialysis patients. Clinical Nephrology, 68(4),222-227.
3 Elsharkawy, M., et al (2006). Intradialytic changes of serum magnesium and their relation to hypotensive episodes in hemodialysis patients on different dialysates. Hemodialysis International, 10, S16-S23.
4 Navarro-Gonzalez,, J., Mora-Fernandez, C., & Garcia-Perez, J. (2009). Clinical implications of disordered magnesium homeostasis in chronic renal failure and dialysis. Seminars in Dialysis, 22(1), 37-44.
5 Raimann, J, et al (2009, November). Fatigue in chronic hemodialysis patients: results from a prospective, randomized, cross-over trial of 200 mg/dL and 100 mg/dL dialysate dextrose concentrations. Poster presentation at 2009 ASN, San Diego, CA.
6 Lacson, E., et al (2009, November). Magnesium and mortality risk in hemodialysis patients. Poster presentation at 2009 ASN, San Diego, CA. Paper submitted for publication.